Top 10 Marijuana Strains for Treating Anxiety, Stress, and Depression

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The use of medical cannabis is widely expanding. Before users only consumed medical marijuana to relieve pain but now, it is a natural remedy you can count on for stress, anxiety, and depression. 

Patients are now aware of their options. There are traditional, chemical-based drugs for the treatment of anxiety and depression but these are known to provide dangerous side effects. Patients now turn to safe and effective medical marijuana for treatment.

Some cannabis strains are great for the relief of stress and you can count on for anxiety. But why is cannabis the best for these mental conditions? What is in cannabis which provides relief?

Why use Medical Cannabis?

Cannabis has natural compounds which are effective for the treatment of different medical as well as mental conditions. Of these compounds, two are more prominent: THC and CBD.

THC or tetrahydrocannabinol is the compound responsible for weed’s psychoactive effects. It can offer relief for anxiety due to its natural mood-elevating properties. And aside from this, THC is also effective for the relief of pain, muscle spasticity, insomnia, glaucoma, low appetite, nausea and so many more conditions

On the other hand, CBD is the therapeutic component of cannabis and has no psychoactive effects. When you take CBD strains, you’ll get relief from anxiety minus any psychoactive effects. You can count on CBD for the relief of anxiety and depression because of CBD’s relaxing properties. CBD can also help with pain, seizures, inflammation, gastrointestinal conditions, nausea, migraines, and other mental conditions.

So which is best for anxiety, stress, and depression?

Proponents of medical marijuana say that although CBD is known as the therapeutic component of cannabis and THC only brings unwanted effects, a strain with the combination of the two compounds is much better with anxiety and stress.

We all know now that THC also has positive therapeutic effects. Meanwhile, CBD has the power to balance THC and thus prevent unwanted side effects. Therefore, a strain with balanced components is better than THC or CBD alone. 

The following list includes strains with nearly balanced components and strains with high THC, known to relieve anxiety. Find out which strain will work best for you.

Best cannabis strains for anxiety, stress, and depression

Granddaddy Purple

Granddaddy Purple is a classic strain which will help you remove all negative thoughts and mental tension. This powerful stress –reliever is an indica strain created by combining a Purple Urkle and a Big Bud. You’ll surely feel relief from tension and stress because of its complex grape and berry taste and aroma.

Granddaddy Purple strain will make you feel relaxed and euphoric just after a few puffs. You will feel your mind wander as your body begins to feel high and very contented. This indica strain will make you very happy and at the same ready to sleep.

Granddaddy Purple is for anxiety and depression. It can naturally relieve negative thoughts and emotions. This strain can also help you conquer insomnia and get that good night’s sleep. It can also help people improve their appetites and help stop nausea and vomiting. This strain is for patients who are undergoing cancer treatment or chemotherapy.

Growing Granddaddy Purple is a challenge for growers because it requires utmost attention and at least a background in growing cannabis. But as long as you provide the growing needs of this strain, no doubt that it will give you good yields.

Jack Herer

Jack Herer is your passport to cerebral elevation. This strain is very potent that after just a few inhales, you will feel very happy and energetic. You will be free from anxiety and stress. You will feel uplifted with all your troubles and worries forgotten.

But compared to other strains for anxiety, you won’t be left with a drifting mind. You‘ll feel focused and ready to work on different tasks at hand. Because of this effect, Jack Herer has been the favorite daytime strain of users suffering from physical and mental fatigue. You may also smoke this in the afternoon if you need continuous energy and stimulation until the end of the day.

Jack Herer is actually a prized therapeutic strain. It has several medicinal benefits including relief from stress and depression because of its natural mood-elevating characteristics. It can uplift mood and stop all negative thoughts.

You can use this to get rid of pain because of its potent natural analgesic effects. You can use this to block out headaches, migraines, muscle spasms and more. With Jack Herer, you can deal with physical and mental fatigue plus boost appetite especially for patients who are undergoing chemotherapy.

When growing Jack Herer, you need not worry even if you’re new to cultivating cannabis. It is easy to grow will flower quickly and has moderate yields.


Cannatonic is your medicinal marijuana strain with high-CBD content. Despite its frightening name, it can soothe you and make you feel relaxed. You’ll be free from anxiety, stress and depressive thoughts in no time when you use Cannatonic.

Cannatonic has 1:1 CBD/THC ratio to block out anxiety, restlessness, paranoia and other side effects of cannabis. What makes this strain better is that it comes with myrcene, a terpene which can improve this strain’s relaxing effects. You will feel pure energy that will make you forget about stress so you can focus on your tasks. Its relaxing effect can calm you and stimulate sleep. And aside from stress and anxiety, this strain is also effective for pain. It can end headaches, muscle strain, and migraines.

When growing Cannatonic, you must be ready to protect this from mold and mildew. But as long as you grow this in a warm climate you can guarantee good yields despite the long flowering time.

Girl Scout Cookies

Girl Scout Cookies or GSC will make you happy as if all your worries have vanished. It has a relaxing effect that may be felt from the head to the tips of your toes. As you continue to enjoy its relaxing effects, you will feel uplifted and positive.

GSC’s effects will eventually fade away and will make you feel very comfortable, sleepy and very hungry. It is a good strain to improve your mood, naturally reduce stress and depression. There is no need to use drugs or synthetic medication to deal with your symptoms.

This strain will also reduce pain because of its potent analgesic effects. It is chosen for the relief of the side effects of chemotherapy or other treatments. This strain is also perfect for relieving mental and physical fatigue.

Girl Scout Cookies is moderately easy to grow. It will give you moderate to high yields and with appropriate training, you can expect to harvest more.


Canna-Tsu is potent CBD-rich strain that will help you deal with anxiety, stress, and depression without making you lose your mind. This is a hybrid strain made by combining Cannatonic and Sour Tsunami which are also high CBD strains. Cannatonic comes with an irresistible sweet and earthy aroma that you can quickly experience on the first inhale and exhale. 

Because of Canna-Tsu’s high CBD content, this will have mellow effects plus alertness and clarity. Strains which have high CBD like Canna-Tsu is preferred by patients who need to block pain and anxiety.

When growing Canna- Tsu, you can expect faster flowering at 9 to 10 weeks and moderate yield. This is easy to grow because it is naturally resistant to molds and pests.  

Strawberry Cough

Strawberry Cough is a very powerful sativa strain with a delicious ripe strawberry aroma. It has an uplifting effect which will last for a long time. You will experience that unending energy flowing through your veins. This will energize you and will make you want to work on different projects with a tune on your lips.

Strawberry Cough can relieve fatigue so you can take on any project. You will feel relaxed as you enjoy a euphoric effect which will keep you grounded to let you deal with any work.

Strawberry Cough’s will work its magic on your confidence during social events. You will be perfect in any situation because you’ll be in control of the situation 100% of the time.

Strawberry Cough is popular for depression and stress. It has mood-elevating properties that will help you deal with negative thoughts. This strain has a natural stress-relieving effect which will help you remove stress naturally. This is a strain that will conquer physical or mental fatigue.

Growing Strawberry Cough is a piece of cake because it is one of the easiest strains to grow. It is extremely resistant to plant diseases, therefore, you’ll grow healthy, high-yielding plants.


ACDC is a high-CBD strain that’s good for people from social anxiety. ACDC has a cannabinoid profile that can vary from one phenotype to another. It has 20 times more CBD than THC which makes it a preferred strain for growers who don’t want to experience any psychoactive effects.

ACDC can make it easier to relax and have a clear-head over negative thoughts. This will help you adapt to any circumstance minus any hair-raising experience.

ACDC is a sativa-dominant strain with a THC: CBD ratio of 1:20 which makes it a good recreational strain as well. This is for patients suffering from pain, anxiety, MS, and epilepsy. You can deal with the unwanted effects of chemotherapy like nausea, vomiting and poor appetite with this strain.

ACDC is a strain for people who are new to growing cannabis. It has quick flowering times and will give you moderate yields. You can further increase the yield of this plant by training this early.

Northern Lights

Northern Lights is a strain that’s not for the faint of heart. It has strong psychoactive effects even in a moderate dose. You’ll feel this throughout your body from your head to your toes. There is a comfortable relaxed feeling which will make you forget all your worries.

And as the effects of this strain begin to wear off, you will feel that overpowering need to sleep. The munchies will soon take over and you’ll want to eat everything you can get your hands on.

Northern Lights comes with moderate THC levels at 20.26% making it a good recreational strain and medical strain. You may use this to reduce stress and depression because of its prominent mood-enhancing effects.

You can count on this strain for insomnia. It is a natural tranquilizer which can reduce sleeplessness and insomnia without dangerous side effects. Northern Lights is also good for pain. Take this regularly so you can finally live free from headaches, muscle pains, and strains, chronic pain, and migraines.

Northern Lights is for novice growers. This is a strain with high resistance to disease and molds. You can grow this indoors or out and get faster flowering and good yields.

White Fire OG

White Fire OG comes with a high THC but is also a good therapeutic strain. Patients prefer White Fire OG because of its high myrcene and limonene content which enhances natural relaxation and stress-relief. This is a great daytime strain that will make you feel relaxed but without getting sleepy.

You can use White Fire OG for social and creative activities perfect for patients with anxiety and depression.  This strain is also for cancer treatment side effects, glaucoma, pain, and lack of appetite.

White Fire OG growers can easily cultivate White Fire OG plants outdoors or indoors. It has quick flowering times and can grow in any environment.

Blackberry Kush

Blackberry Kush is a potent indica that comes with a strong sedating effect. This was made by combining the powerful genes of an Afghani and Blueberry strain. The effect is potent but won’t last for a very long time.

Blackberry Kush is a potent recreational and medicinal strain as well. You can use this for stress and depression because of its powerful mood-elevating properties.

This indica grows fast and flowers fast in just 7 to 8 weeks. It has moderate yields and you can improve this by training your precious plants early.

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